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Process development

Upstream process development

CAHT has R&D laboratory and pilot production laboratory, equipped with advanced instruments and equipment, and the culture scale can meet the cultivation needs of 1L to 100L, supporting Fed-Batch and Perfusion process development platforms.
We can help you:
  • 01
    culture medium screening
  • 02
    Selection of fed-medium and development of fed-strategy
  • 03
    Development of culture process
  • 04
    Process characterization and process validation

Downstream technology features and cutting-edge process solutions

With a set of domestic technology leading monoclonal antibody downstream process platform, has a young and vigorous technical research team, equipped with a group of technical backbone with many years of production experience for the follow-up process amplification and accurate implementation of the elite team.
The main processes include clarification harvesting, protein A affinity capture, decontamination with detergent or low pH virus inactivation, one to two step ion-exchange chromatography purification, virus filtration and ultrafiltration/diafiltration.
All downstream equipment are from Europe and the United States, such as: PALL, Cytiva, Sartorius and other internationally renowned biopharma suppliers.
  • 01
    Harvest Clarification
  • 02
    Protein A affinity capture
  • 03
    Detergent or low pH virus inactivation
  • 04
    purified by ion exchange chromatography
  • 05
    Virus Filtration
  • 06
    Ultrafiltration / Diafiltration
Development services
Development services
CAHT high-tech cooperation with you

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Development services
CAHT high-tech cooperation with you

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